Efficacy of Chlorhexidine Versus Listerine Perioperative Mouthwash in Preventing Ventilator-Acquired Pneumonia: An Integrative Review
Repository Posting Date2018-05-11T18:22:34Z
Author(s)Clements, James Owen
TypeOther Graduate Paper
Level of EvidenceLiterature Review
Research ApproachTranslational Research/Evidence-based Practice
CINAHL HeadingsPneumonia, Ventilator-Associated--Prevention and Control; Mouthwashes; Dental Plaque--Prevention and Control; Chlorhexidine; Pneumonia, Ventilator-Associated; Dental Plaque
Objective: To compare the safety and efficacy of chlorhexidine versus Listerine in perioperative and intensive care settings in preventing ventilator-acquired pneumonia (VAP).
Methods: An integrative review using a keyword search was conducted in Cochrane, Cinahl, and Google Scholar databases. Data was collected regarding the efficacy of chlorhexidine and Listerine in preventing ventilator-acquired pneumonia, safety and side effect profiles, and in vivoin vitro secondary outcome measures.
Results: Chlorhexidine demonstrates superiority to Listerine in reducing ventilator-acquired pneumonia. Secondary in vivo tests including plaque and gingivitis reduction, and in vitro tests measuring the effect on bacterial loads, also favors chlorhexidine over Listerine. Chlorhexidine has shown to have significantly more side effects compared to Listerine.
Conclusions: Chlorhexidine is justifiably used in preventing ventilator-acquired pneumonia over Listerine. There is a gap in knowledge due to the lack of randomized-controlled trials utilizing Listerine in VAP bundles. Future research should focus on finding an alternative mouthwash to chlorhexidine that is equally effective at reducing VAP incidence, but lacks chlorhexidine’s undesirable side effect profile.