Ondansetron Administration Prior to Subarachnoid Block in Cesarean Section: An Evidence Based Practice Analysis
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Subarachnoid block (SAB) is a preferred regional technique utilized by many institutions for caesarean section. A sensory block height of T5 is necessary for a successful caesarean under SAB. Unfortunately, side effects often emerge related to the physiological changes as a result of sympathetic nervous system inhibition. Current research suggests up to 55%-90% of parturients experience extended block height resulting in hypotension and bradycardia.There is a reduction in cardiac output due to a decrease in systemic vascular resistance and venous pooling. Similarly, the shift of cardiac autonomic balance toward parasympathetic stimulation causes bradycardia and activation of left ventricular mechanoreceptors due to a decreased ventricular volume. The mechanism is known as the Bezold-Jarisch reflex (BJR).
| Type | Other Graduate Paper |
| Acquisition | Proxy-submission |
| Review Type | Faculty Approved: Degree-based Submission |
| Format | Text-based Document |
| Evidence Level | N/A |
| Research Approach | N/A |
| Keywords | Bezold-Jarisch reflex; bradycardia; Cesarean Section; hypotension; ondansetron; subarachnoid block |
| CINAHL Subject(s) | Cesarean Section; Ondansetron--Administration and Dosage; Hypotension--Etiology; Anesthesia, Spinal--Adverse Effects--In Pregnancy; Reflex; Ondansetron; Hypotension; Anesthesia, Spinal--Adverse Effects; Anesthesia, Spinal |
| Grantor | Bryan College of Health Sciences |
| Advisor | Hadenfeldt, Sharon |
| Level | Doctoral – Other |
| Year | 2017 |
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