70% ethanol for decontamination of central venous lines exposed to calcineurin inhibitors
View File(s)
- Author(s)
- Details
-
Jessica Ann Copacia, APN; Kimberly Taylor, APN; Melissa Laudick, APN; Rolla Abu-Arja, MD; Jeffery J. Auletta, MD; Hemalatha G. Rangarajan, MD; Amy Pyle-Eilola, PhD; Joseph Stanek, MS; Vinita B Pai, Pharm D, MS; Rajinder Bajwa, MBBS, MRCP, MD
- Sigma Affiliation
- Non-member
Visitor Statistics
Visits vs Downloads
Visitors - World Map
Top Visiting Countries
Country | Visits |
---|
Top Visiting Cities
City | Visits |
---|
Visits (last 6 months)
Downloads (last 6 months)
Popular Works for Copacia, Jessica Ann by View
Title | Page Views |
---|
Popular Works for Copacia, Jessica Ann by Download
Title | Downloads |
---|
View Citations
Citations
Introduction: Tacrolimus, commonly used for GvHD prophylaxis is usually administered via a dedicated CVL and trough levels drawn from the unexposed lumen. Being an oil-based medication, it may be adsorbed to the inside lumen of the CVL and result in falsely high levels drawn from an inadvertently exposed lumen. There is no treatment for decontamination of such CVLs and natural decay occurs over months before the CVL can be used to draw reliable trough levels. Methods: We studied the efficacy of 70% ethanol lock in decontaminating CVLs exposed to tacrolimus in children during transplant. Trough tacrolimus levels were drawn from the exposed and unexposed (control) lumens at 8:00AM, followed by a 2 ml 70% ethanol lock instilled for a 2hour dwell into the exposed (intervention) lumen. Trough tacrolimus levels were again drawn from both lumens at 8:00PM and levels compared for efficacy. Results: All 20 sets showed a high 8am trough level in the exposed intervention arm (median = 30 ng/ml) to be significantly greater (p < .0001) than the control arm (median = 9.05 ng/ml) and were contaminated. After the 2h ethanol lock, 65% of the lumens were decontaminated. The difference between the control and intervention arms were no longer found to be statistically significant (p = 0.0826). Conclusion: A 2hour 70% ethanol lock is effective for decontamination of CVLs exposed to tacrolimus. These results will help to easily fix a tenacious problem encountered in the allogeneic HSCT field.
The information contained in this report formed the basis of a manuscript published as the following: Copacia, J. A., Taylor, K., Laudick, M., Abu-Arja, R., Auletta, J. J., Rangarajan, H. G., … Bajwa, R. (2013). 70% Ethanol for Decontamination of Cvl Exposed to Calcineurine Inhibitors. Biology of Blood and Marrow Transplanatation, 22(3), S287. doi: http://dx.doi.org/10.1016/j.bbmt.2015.11.739
;This material was also presented as a poster at the 2016 ASBMT Tandem meetings in Honolulu, Hawaii.
;Disseminating this report in an open-access repository does not violate the policies and rights of the journal.
Type | Research Study |
Acquisition | Self-submission |
Review Type | Peer-review: Single Blind |
Format | Text-based Document |
Evidence Level | Other |
Research Approach | Quantitative Research |
Keywords | Calcineurin Inhibitor; Tacrolimus; Ethanol; Lock Therapy; Graft Versus Host Disease |
CINAHL Subject(s) | Ethanol; Ethanol--Therapeutic Use; Catheterization, Central Venous; Catheterization, Central Venous--Adverse Effects; Catheter-Related Infections; Catheter-Related Infections--Prevention and Control; Central Venous Catheters; Graft Versus Host Disease |
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Related items
Showing items related by title, author, creator and subjects.
-
Reduced central line-associated bloodstream infection by application of integrated evidence-based care bundle in critically ill patients
Shiung, Tao-Fen; Lu, Shu-Fen; Chou, Shin-shang (2012-01-04)Central venous catheter-associated bloodstream infections (CBI) are frequent causes of morbidity and mortality in intensive care units (ICU). The purpose of this study is to apply an integrated evidence-based care bundle ... -
Nursing care in peripheral intravenous catheter: Impact on microbiological profile
Graveto, Joao Manuel; Santos, Daniela Vidal; Oliveira, Anabela de Sousa Salgueiro; Osorio, Nadia (2016-07-13)Session presented on Sunday, July 24, 2016: Purpose: The peripheral intravenous cannulation is the most common form of administration of intravenous therapy used in hospitals, being nurses the professional responsible for ... -
Effectiveness of central venous catheter needleless connectors & protective caps in reducing central line associated blood stream infections
Nelson, Susan K (2015-01-15)Session presented on Thursday, September 25, 2014: Background and Significance: There are approximately 250,000 central line-associated blood stream infections (CLABSI) in the U.S. each year. The CLABSI mortality rate in ... -
Best clinical practice of disinfection in intravenous device therapy contaminated with Klebsiella pneumoniae
Dalcin, Camila Biazus; Rocha, Patrícia Kuerten; Sincero, Thaís Cristine Marques; Pina, Juliana Coelho; Souza, Sabrina; Lomba, Maria LurdesKlebsiella pneumoniae is a Gram-negative bacteria. The treatment of infections from this bacteria in children is more challenging due to limited appropriate antibiotic use in this specific group (Akturk et al., 2016). ... -
Reduction of catheter-related bloodstream infections rate in medical center in Taiwan
Liu, Ya-Yun; Liao, Shu-Chen; Lin, Li-Gin; Chen, Pei-Yi (2016-07-13)Session presented on Thursday, July 21, 2016 and Friday, July 22, 2016: Purpose: We designed a project to reduce the CRBSI rate below 4.0% in our intensive care unit, further enhance the quality of care of critically ill ...