The cervical microbiome and parturition
View File(s)
- Author(s)
- Details
-
Marie Hastings-Tolsma, PhD, CNM, FACNM; Mary Ann Faucher, PhD, MPH, MS, BS, RN, CNM, FACNM
- Sigma Affiliation
- Non-member
Visitor Statistics
Visits vs Downloads
Visitors - World Map
Top Visiting Countries
Country | Visits |
---|
Top Visiting Cities
City | Visits |
---|
Visits (last 6 months)
Downloads (last 6 months)
Popular Works for Hastings-Tolsma, Marie by View
Title | Page Views |
---|
Popular Works for Hastings-Tolsma, Marie by Download
Title | Downloads |
---|
View Citations
Citations
Session presented on Thursday, 21 July 2016 and Friday, 22 July 2016:
Purpose: The importance of the microbes that reside in and on the human body are increasingly recognized for the action they carry out, influencing human health, behavior, and disease through immunologic, endocrine, and neural pathways. The National Institutes of Health completed the Human Microbiome Project and is now engaged in the integrative Human Microbiome Project 2 which aims to examine changes in the microbiome and human health. While many body sites have been examined, there has been little study of the cervix and myometrium, two key reproductive tissues that hold promise for better understanding of significant perinatal problems such as preterm birth. The purpose of this exploratory research is three-fold: 1) describe the indigenous microbiota in late pregnancy and parturition, 2) provide preliminary data regarding the corresponding indigenous myometrial microbiota, 3) characterize the cervical microbiotic patterns contributing to normal physiologic birth outcomes.
Methods: This research enrolls 20 healthy pregnant white women, 18-35 years of age, with normal body mass index (BMI), and who present for prenatal care at a birth center in the Southwest United States. Women enrolled in this prospective study have cervical specimens collected at 2 points: at 35-37 weeks and at the onset of labor. Where the participant has a Cesarean birth, a myometrial specimen is obtained to provide preliminary data regarding microbiota community taxonomic composition and diversity and how that compares with that found in the cervix. A standardized collection and processing model is being used to swab the cervix with preservation of samples by immediate freezing. Demographics, baseline clinical characteristics, and select perinatal outcomes are examined in relation to the community of microbes noted in the cervix. Dietary intake (24 hour recall) - a select host factor is also examined for consideration of potential impact on noted microbiota and associated perinatal outcomes.
Results: Data will be analyzed to characterize the cervical and uterine microbial communities and determination of correlations between differences in the microbiome and perinatal outcomes with microbiome compositions being measured by 16S rRNA gene sequencing.
Conclusion: The goal of this research is to promote health in pregnancy and improve perinatal outcomes. Findings have the potential for further refinement of personalized medicine for pregnant women, including development of biomarkers which could be key in the development of targeted interventions capable of promoting or blocking parturition at less desirable endpoints.
Theme: Leading Global Research: Advancing Practice, Advocacy, and Policy
Items submitted to a conference/event were evaluated/peer-reviewed at the time of abstract submission to the event. No other peer-review was provided prior to submission to the Henderson Repository.
Type | Poster |
Acquisition | Proxy-submission |
Review Type | Abstract Review Only: Reviewed by Event Host |
Format | Text-based Document |
Evidence Level | N/A |
Research Approach | N/A |
Keywords | Cervical Microbiota; Parturition; Pregnancy |
Name | 27th international Nursing Research Congress |
Host | Sigma Theta Tau international |
Location | Cape Town, South Africa |
Date | 2016 |
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Related items
Showing items related by title, author, creator and subjects.
-
A systematic review of gestational weight gain by obese women and maternal/newborn outcomes
Faucher, Mary Ann (2013-10-22)Session presented on: Wednesday, July 24, 2013: Purpose: A systematic review of gestational weight gain (GWG) in obese women, stratified by obesity severity, evaluated a mix of maternal and newborn outcomes, since the ... -
Factors influencing gastrointestinal microbiota during pregnancy
Chung, Seon-Yoon; Ravel, Jacques; Regan, Mary (2017-10-24)We present evidence related to factors that influence the structure, and subsequently function, of gastrointestinal(GI) microbiota in the general and pregnant population. Clinicians can benefit from understanding the ... -
Evidence-based research and delayed cord clamping: Implications for cross-cultural education, research, and policy
Faucher, Mary Ann (2017-07-14)Purpose: Conduct an educational capacity building research initiative for nurse midwives in India to improve iron status of newborns by delaying the clamping of the umbilical cord at birth. In India, iron deficiency ... -
The impact of gut microbiota changes among colon cancer patients undergoing surgery: A prospective study
Pellazgu, EleniThe purpose of this study is to gain a better understanding of whether changes in the human microbiome can be correlated with changes in human health including clinical outcomes, patient-reported outcomes, and diet tolerance. -
Experiences of Vietnamese marriage immigrant women with pregnancy, birthing, and postpartum vare in Korea
Kim, Sun-Hee; Lee, Yu-Jin (2014-11-17)Session presented on Saturday, July 26, 2014: Purpose: Korea used to be a nation with homogeneous racial composition has become a multicultural country with foreigners making up 2.8% of total population due to influx of ...