Pain, gut microbiome and neurodevelopment in preterm infants
View File(s)
Visitor Statistics
Visits vs Downloads
Visitors - World Map
Top Visiting Countries
Country | Visits |
---|
Top Visiting Cities
City | Visits |
---|
Visits (last 6 months)
Downloads (last 6 months)
Popular Works for Cong, Xiaomei by View
Title | Page Views |
---|
Popular Works for Cong, Xiaomei by Download
Title | Downloads |
---|
View Citations
Citations
Session presented on Thursday, July 21, 2016:
Purpose: The purpose of this presentation is to discuss the state-of-the-science of recent research for the importance of the brain-gut-microbiota axis in regulation of pain/stress in early life and the use of advanced technologies of microbiome genomic sequencing in predicting pain/stress responses and neurodevelopmental outcomes in high risk preterm infants.
Methods: A prospective longitudinal study was conducted. Sixty preterm infants (26 0/7 - 32 6/7 weeks gestational age) were recruited at birth and followed-up for 3 weeks. Outcome measurements are gut microbiota (16S rRNA and metagenomic sequencing), early life pain/stress experience, and neurodevelopmental outcomes. Stool samples and pain/stress levels were measured daily and neurodevelopmental outcomes were examined at 35-36 weeks post-menstrual age prior to NICU discharge. Exploratory data analysis was conducted with a focus on the evolution in each variable's distribution over time and linkages among variables. The associations of pain/stress, gut microbiome diveristy and abundance of specific bacteria, and neurodevelopmental outcomes were analyzed using mixed effect models.
Results: Preterm infants experienced large amount of painful/stressful event in their early life during the NICU stay. Accute and chronic pain/stressors were significant predictors for neurodevelopmental responses. Preterm infants' gut microbiome patterns were diverse among individual infants. Pain/stressor scores account for greater than 10% of the variability seen in the microbiome community and there is an association between the gut microbiome diversity and neurodevelopmental outcomes. Indicator species analysis showed that infant who experienced less pain during NICU stay had higher abundance of Bacteroides and Lactobacillus, while infant who experienced more painful events had higher abundance of Pantoea and Aeromonadaceae (Proteobacteria phyla), which are potential pathogens in infant intestinal tract.
Conclusion: The brain-gut signaling system and the role of the gut microbiome are remarkably related to pain/sress in early life. Understanding mechanisms by which early life experience alters neurodevelopment via the brain-gut-microbiota axis will help clinicians to develop neuroprotective strategies to better predict outcomes and to provide corresponding interventions.
Theme: Leading Global Research: Advancing Practice, Advocacy, and Policy
Items submitted to a conference/event were evaluated/peer-reviewed at the time of abstract submission to the event. No other peer-review was provided prior to submission to the Henderson Repository.
Type | Presentation |
Acquisition | Proxy-submission |
Review Type | Abstract Review Only: Reviewed by Event Host |
Format | Text-based Document |
Evidence Level | N/A |
Research Approach | N/A |
Keywords | Pain; Gut Microbiome; Preterm Infants |
Name | 27th international Nursing Research Congress |
Host | Sigma Theta Tau International |
Location | Cape Town, South Africa |
Date | 2016 |
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Related items
Showing items related by title, author, creator and subjects.
-
Perinatal corticosteroids: Latent neurodevelopment of the preterm infant
Purdy, Isabell BieneThe purpose of this study was to evaluate potential relationships between perinatal dexamethasone treatment of premature infants and latent child development. Often, postnatal corticosteroid (PNS) is offered in the neonatal ... -
Integration of evidence for genetic risk of abnormal neurodevelopment in preterm infants
Blair, Lisa M.; Pickler, Rita H.; Anderson, Cindy M. (2016-03-21)Session presented on Saturday, November 7, 2015 and Sunday, November 8, 2015: Problem: Preterm infants are at elevated risk for a host of atypical neurodevelopmental problems, including disorders that appear later in life. ... -
Change in caregiving activities in preterm infants over the first 14 days of life
Brandon, Debra H.; Vance, Ashlee (2017-07-26)High-risk term and preterm infants are most vulnerable to an altered microbiome due to the atypical Neonatal Intensive Care Unit (NICU) environment. This study described the frequency and changes in caregiving activities ... -
Oral breast milk combined with sensory interventions relieve preterm infant pain during short painful procedures
Liaw, Jen-Jiuan; Wu, Hsiang-Ping; Peng, Hsueh-Fang; Lan, Hsiang-Yun; Ti, YinOral presentation using PPTs to introduce my significant studies. Show some photos and video recordings to emphasize the benefit of natural breast milk in relieving pain in preterm infants. -
Integration of different sensory interventions from mother's breast milk for preterm infant pain during venipunctures
Liaw, Jen-Jiuan; Wu, Hsiang-PingThe study suggests that integration of mother's breast milk odor or taste, heartbeat sounds, and tactile non-nutritive sucking should be considered as an intervention for alleviation of procedural pain for preterm infants. ...