Procalcitonin as a prognostic indicator of risk for sepsis in the neonate
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Tara L. Cecil, RN, DNP, MSN, BSN, APRN, CPNP-AC
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Introduction. Procalcitonin (PCT) is a biomarker that rises at the onset of bacterial infection while remaining relatively low in other inflammatory processes. Diagnosing serious bacterial infection (SBI) in neonates presenting with fever without a source (FWS) is challenging and utilizing PCT can improve this process. This paper presents a synthesis of the evidence supporting PCT as a prognostic indicator in neonates.
Methodology. A comprehensive literature review was conducted to develop practice recommendations. A guideline, the Intermountain Healthcare Care Process Model (2013), was modified to include PCT, which was then validated by a panel of clinical experts.
Results. Evidence supports the use of PCT as a prognostic indicator. Clinical expert feedback supports using the modified Intermountain Healthcare Care Process Model (2013) in practice.
Discussion. PCT is a valuable serum biomarker that should be examined in the workup of neonates presenting with FWS and a modified algorithm to include PCT is presented.
This work has been approved through a faculty review process prior to its posting in the Virginia Henderson Global Nursing e-Repository.
Type | DNP Capstone Project |
Acquisition | Self-submission |
Review Type | Faculty Approved: Degree-based Submission |
Format | Text-based Document |
Evidence Level | Clinical Practice Guideline(s) |
Research Approach | Translational Research/Evidence-based Practice |
Keywords | Procalcitonin; Neonatal; Sepsis; Serious Bacterial Infection; Fever Without a Source |
CINAHL Subject(s) | Calcitonin; Calcitonin--Blood; Sepsis--Prognosis; Sepsis; Neonatal Sepsis; Fever of Unknown Origin; Bacterial Infection |
Grantor | Northern Arizona University |
Advisor | Saulpaugh, Janine; Umberger, Paul Repass III; Watkins, Katherine Dolan |
Level | DNP |
Year | 2016 |
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