Meta-analyses of epigenetics risk factors for lung cancer prevention: MPO and GSTM1 human gene variations across different race-ethnicity groups
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Po-Jui Yu, MSN, RN; Shyang-Yun Pamela K. Shiao, PhD, RN, FAAN; Maria Suarez, MSN, RN
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- Lambda Beta at-Large
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Session presented on Monday, July 28, 2014:
Purpose: The purpose of this presentation is to disseminate current evidence on population genome health, through meta-analyses of epigenetic risk factors, for lung cancer (LC) prevention. LC is one of the most common cancers worldwide and has the highest mortality rate among all cancers. Glutathione S-transferase that belongs to the mu class (GSTM1) and myeloperoxidase (MPO) gene polymorphisms have been cumulating in the literature, associating epigenetics factors and LC.
Methods: Literature searches, quality scores for the studies, and inter-rater evaluation on data coding was completed to ensure data accuracy for pooled meta-analyses.
Results: Preliminary analyses included 31,146 LC cases and 38,736 controls from 122 studies. The MPO gene mutations (GA and AA subtypes) in Asians were lower (16.7-33.3%) than Caucasians (31.8-49.1%) across the world, for control and case groups. However, the GSTM1 gene mutation variation (null subtype) was highest in Italians (87.5%) than other populations. Pollution indicators were checked and shown worse in Asia than other countries. For lifestyle related meta-analyses, smoking was associated with an increased risk of LC (98 studies, 28,831 cases, 35,069 controls, RR=1.40, p < 0.0001). Low vegetable intakes were associated with increased LC risk (RR = 1.26, P < 0.05) in 7 studies. No second hand smoking (6 studies) and limiting indoor pollution (3 studies) were protective for LC (RR=0.73 and 0.77, both P<0.05).
Conclusion: For association of GSTM1 gene variations, genotype present (44.3% cases, 47.9% controls) was protective against LC for all populations combined in the world (RR = 0.94, p < 0.0001). Future studies are needed to examine epigenetic factors for population health associated with MPO and GSTM1 gene variations in the prevention of LC.
International Nursing Research Congress, 2014 Theme: Engaging Colleagues: Improving Global Health Outcomes. Held at the Hong Kong Convention and Exhibition Centre, Wanchai, Hong Kong
Items submitted to a conference/event were evaluated/peer-reviewed at the time of abstract submission to the event. No other peer-review was provided prior to submission to the Henderson Repository.
Type | Presentation |
Acquisition | Proxy-submission |
Review Type | Abstract Review Only: Reviewed by Event Host |
Evidence Level | N/A |
Research Approach | N/A |
Keywords | Meta-Analyses; Epigenetics; Lung-Cancer |
Name | 25th International Nursing Research Congress |
Host | Sigma Theta Tau International |
Location | Hong Kong |
Date | 2014 |
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