Preoperative tranexamic acid use in secondary postpartum hemorrhage
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Katie Waid, BSN and Mary Beth Greenway, DNP, CRNA
- Sigma Affiliation
- Non-member
Postpartum hemorrhage (PPH) is the leading cause of maternal mortality worldwide and is defined as blood loss greater than 1,000 mL, or blood loss with symptoms of hypovolemia. Primary PPH arises within 24 hours of delivery, while secondary PPH occurs within 12 weeks of delivery. Tranexamic acid (TXA) is an antifibrinolytic that inhibits plasminogen and fibrin binding, thus preventing fibrinolysis and promoting hemostasis. Although uterotonic agents remain the pillar for prevention and treatment of PPH, recent evidence indicates that TXA given prophylactically or as treatment can reduce postpartum blood loss.
| Type | DNP Capstone Project |
| Acquisition | Self-submission |
| Review Type | None: Degree-based Submission |
| Format | Text-based Document |
| Evidence Level | Case Study/Series |
| Research Approach | Translational Research/Evidence-based Practice |
| Keywords | Postpartum Hemorrhage; Blood Loss; Antifibrinolytic; Prevention Measures |
| Grantor | Samford University |
| Advisor | Greenway, Mary Beth |
| Level | Doctoral-Other |
| Year | 2023 |
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