Evidence for human placental SLC6A4 dysregulation in prenatal opioid and alcohol exposure
Sharon Ruyak1, PhD, CNM, RN; Shahani Noor 2; Melody Sun2; Annette Frenandez Oropeza2; Jared DiDomenico3; Dominique Rodriguez3; Lidia Enriquez Marquez2; Ludmila Bakhireva3; Erin Milligan2 - 1College of Nursing, 2Department of Neurosciences, 3College of Pharmacy
- Sigma Affiliation
- Gamma Sigma
- Contributor Affiliation(s)
- The University of New Mexico, Albuquerque, New Mexico, USA
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The purpose of this project was to address the convergent effect of POE and PAE on key placental immune and serotonin factors. The central hypothesis was that increased opioid-induced activation of the TLR4 pathway in the placenta results in dysregulated immune cytokine expression and serotonin function and this relationship will be magnified in POE and PAE placental tissue.
The Sigma Theta Tau International grant application that funded this research, in whole or in part, was completed by the applicant and peer-reviewed prior to the award of the Sigma grant. No further peer-review has taken place upon the completion of the Sigma grant final report and its appearance in this repository.
Dr. Ruyak was the recipient of the Sigma/Western Institute of Nursing Research Grant, 2019-2020 cohort.
|Review Type||None: Sigma Grant Recipient Report|
|Research Approach||Quantitative Research|
Placental Immune Factors;
Dsyregulated Immune Cytokine Expression
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