Coadministration of ketamine and magnesium: An integrative review
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Abstract
Objective: The object of this integrative review was to investigate the analgesic benefit and side effect profile of the coadministration of ketamine and magnesium. Secondary goals were to provide an evidence-based recommendation on the ideal dosing, frequency, and order of administration of the medications. Methods: Relevant articles published between January 2001 and May 2019 were examined for quality, strength, and generalizability. Results: Beginning evidence suggests ketamine may interact with magnesium to provide synergistic NMDA receptor antagonism and analgesia. Evidence from animal studies proposes that order of administration may influence potency, with ketamine prior to magnesium producing better analgesia. Coadministration of ketamine and magnesium in low doses intended for analgesia did not result in a significant increase in side effects in these studies. While stronger evidence is needed, the coadministration of ketamine and magnesium may provide synergistic analgesic benefit without an increase in side effects.
Repository Posting Date
2021-01-21T18:12:58Z
Type Information
Type | Other Graduate Paper |
Acquisition | Proxy-submission |
Review Type | Faculty Approved: Degree-based Submission |
Format | Text-based Document |
Category Information
Evidence Level | Other |
Research Approach | Translational Research/Evidence-based Practice |
Keywords | Ketamine; Magnesium; Coadministration; Synergism; Analgesia |
Degree Information
Grantor | Bryan College of Health Sciences |
Advisor | Pecka, Shannon |
Level | Doctoral-Other |
Year | 2020 |
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