The relationship between the abnormal electrophysiological features and the degeneration in cognition, behavior, daily functioning, and global presentation manifested by individuals with Alzheimer's disease
Dr. Ezra C. Charles Holston, PhD, RN
- Sigma Affiliation
Visits vs Downloads
Visitors - World Map
Top Visiting Countries
Top Visiting Cities
Visits (last 6 months)
Downloads (last 6 months)
Popular Works for Holston, Ezra C. Charles by View
Popular Works for Holston, Ezra C. Charles by Download
Alzheimer's disease (AD) is an increasingly prevalent neurologic disorder characterized by progressive degeneration in cognition, behavior, and daily functioning. Identification of methods designed to enhance the accuracy and efficiency of early diagnosis would allow for proactive care including timely implementation of treatment modalities. Toward this goal, this secondary analysis was designed to examine the relationship between clinical symptoms (cognitive, behavioral, and daily functioning) and abnormal electrophysiological features in individuals with AD. The sample included 100 community-residing adults, aged 50–89 years, and ranged from normal-functioning elderly to those diagnosed with severe AD. The baseline (BL) and follow-up (FU) diagnostic data were extracted for analysis from two full databases. Neuropsychological data included the Global Deterioration Scale (GDS), the Mini Mental Status Examination (MMSE), the Behavioral Pathology in Alzheimer's disease Rating Scale (BEHAVE-AD), and the Functional Assessment Staging of Alzheimer's disease (FAST). Electrophysiological data included neurometric quantitative electroencephalogram (qEEG) using the 10/20 International System. A moderately strong relationship (|r| = .38–.66, p ≤ .001) existed between abnormal electrophysiological features and clinical symptoms in community-residing adults with AD. A multivariate set of BL abnormal electrophysiological features explained 86% of the variance in a multivariate set of FU clinical symptoms with canonical correlations. A backward deletion multiple regressional model demonstrated that a predictor of multivariate BL abnormal electrophysiological features explained a minimum of 50% of the variance in individual FU clinical symptoms. The earliest preclinical symptoms observed were degeneration in daily functioning skills, absolute/relative delta deficit, and absolute/relative/mean frequency theta excess in frontal regions of normal-functioning elderly. Theta excess in absolute power, relative power, and mean frequency was prominent and diffusely progressed from the frontal regions to the posterior, from mild cognitive impairment (MCI) to severe AD. Behavioral degeneration, as indicated by a mean of 0.5±1.4 at stage FU GDS 2, was manifested before cognitive degeneration. The findings suggest that inclusion of electrophysiological evaluation enhances early, accurate diagnosis of AD. Longitudinal outcome studies of the relationship between abnormal electrophysiological features and clinical symptoms are suggested to inform interventions designed to delay and prevent the progression of AD.
This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 3100793; ProQuest document ID: 305313893. The author still retains copyright.
This item has not gone through this repository's peer-review process, but has been accepted by the indicated university or college in partial fulfillment of the requirements for the specified degree.
|Review Type||None: Degree-based Submission|
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Showing items related by title, author, creator and subjects.
Utilizing an individualized music playlist and a receptive music approach to reduce agitation in hospitalized patients with dementia as evidenced by the Agitated Behavior Scale (ABS) Moreno Lee, Michelle; Harris, MaryThe number of patients with Dementia (PwD) admitted to acute care hospitals is increasing worldwide. Prolonged hospital stays are associated with a deterioration in cognitive, functional, and physiological status (Mathews, ...
The relationship of stroke patients' functional and cognitive status and caregivers' resilience to caregiver burden Nolan, Margaret D.Currently it is estimated that 795,000 persons experience a stroke every year. Of that number up to one-third of survivors will be permanently disabled. It is neither financially feasible nor desirable to place these ...
The Relationships Between Exercise Behavior and Sleep Quality and Their Related Factors Among COPD Patients Chen, Pei-Ju; Chiang, Chi-Huei; Wang, Kwua-Yun; Yao, Kaiping; Perng, Wann-Cherng (2012-9-12)Purpose: The purpose of this study will investigate the relationships between exercise behavior and sleep quality and their related factors among COPD patients. Methods: The cross-sectional and descriptive designed will ...
The relationship between the stage of moral development and the frequency of dishonest behaviors in the classroom and clinical setting in baccalaureate nursing students Cooper, Diann C.Nursing is consistently ranked for its honesty and integrity. It is guided by a set of standards for ethical practice. However, nursing students participate in academic dishonesty at rates similar to non-nursing students. ...
Mother-child relationship, adolescent daily hassles, and adolescent behavior problems in Arab Muslims: A latent growth curve approach Aroian, Karen; Templin, Thomas; Hough, Edythe (2013-10-22)Session presented on: Friday, July 26, 2013: Purpose: Our previous research findings about Arab Muslim youth documented that adolescent daily hassles and poor quality of mother-child relationships had strong direct effects ...