Cognitive function in breast cancer patients undergoing chemotherapy
Catherine E. Jansen, PhD, Oncology Clinical Nurse Specialist
- Sigma Affiliation
- Alpha Eta
Visits vs Downloads
Visitors - World Map
Top Visiting Countries
Top Visiting Cities
Visits (last 6 months)
Downloads (last 6 months)
Popular Works for Jansen, Catherine E. by View
Popular Works for Jansen, Catherine E. by Download
Background. Recent studies suggest that standard dose chemotherapy (CTX) may cross the blood-brain barrier. However, the evidence for CTX-induced cognitive impairments in breast cancer patients is inconsistent. Purposes. (1) to describe the literature about CTX-induced cognitive impairments in women with breast cancer; (2) to review the domains of cognitive function and their corresponding neuroanatomic structures as well as present current evidence for neurotoxicity associated with specific CTX agents and potential mechanisms for CTX-induced cognitive impairments; (3) to estimate the effect sizes for the effect of CTX on each domain of cognitive function; (4) to determine the sensitivity of neuropsychological tests which have been used to evaluate CTX-induced impairment in various domains of cognitive function in breast cancer patients; and (5) to assess changes in cognitive function over time in breast cancer patients receiving CTX, and evaluate potential relationships between cognitive function and anxiety, depression, fatigue, hemoglobin levels, menopausal status, and perceived cognitive function. Methods. We performed meta-analyses to measure effect sizes to determine CTX effect on various domains of cognitive function and to determine neurological test sensitivity. In the longitudinal study, we recruited a multicultural sample of thirty women with breast cancer for neuropsychological testing prior to the initiation and a week after completion of treatment with doxorubicin and cyclophosphamide CTX. Paired t-tests were used to evaluate changes in cognitive scores over time and linear mixed modeling was used to determine whether significant changes remained after controlling for anxiety, depression, fatigue, hemoglobin level, menopausal status, and perceived cognitive function. Findings. Only two domains of cognitive function (i.e., language, visual memory) had small albeit significant negative effect sizes in the meta-analysis of CTX-induced cognitive impairments in breast cancer patients. We evaluated thirty tests used to measure cognitive changes in breast cancer patients who received CTX, but found only six tests to be sensitive in detecting changes in four of eight domains of cognitive function (i.e., language, motor function, visuospatial skill, and verbal memory). In the longitudinal study significant decreases in cognitive function were found after CTX in visuospatial skill (p ≤ .001) and total cognitive (p = .001) scores over time.
This dissertation has also been disseminated through the ProQuest Dissertations and Theses database. Dissertation/thesis number: 3261235; ProQuest document ID: 304878866. The author still retains copyright.
This item has not gone through this repository's peer-review process, but has been accepted by the indicated university or college in partial fulfillment of the requirements for the specified degree.
|Review Type||None: Degree-based Submission|
|Research Approach||Quantitative Research|
|CINAHL Subject(s)||Breast Neoplasms--Drug Therapy;
Chemotherapy, Cancer--Adverse Effects;
Cognition Disorders--Chemically Induced;
All rights reserved by the author(s) and/or publisher(s) listed in this item record unless relinquished in whole or part by a rights notation or a Creative Commons License present in this item record.
All permission requests should be directed accordingly and not to the Sigma Repository.
All submitting authors or publishers have affirmed that when using material in their work where they do not own copyright, they have obtained permission of the copyright holder prior to submission and the rights holder has been acknowledged as necessary.
Showing items related by title, author, creator and subjects.
Myers, Jamie S.The aims of this qualitative descriptive study were to describe the experience of chemotherapy-related cognitive impairment (CRCI) for women with breast cancer who received chemotherapy; and identify information about CRCI ...
Kanaskie, Mary LouiseBackground: Change in cognitive function is one side effect of chemotherapy that has been reported in some breast cancer survivors. Alarming reports indicate that between 16 to 50 percent of women receiving chemotherapy ...
Efficacy of acupressure treatment at Neiguan Point with acupressure bands for chemotherapy-induced nausea, vomiting, and retching Meyer, Christine D.Patients who receive chemotherapy perceive nausea and vomiting (N&V) to be one of the most problematic outcomes of chemotherapy. Even with the administration of a prophylactic antiemetic protocol, up to 33% of the patients ...
Menopausal symptoms and quality of life in breast cancer patients undergoing chemotherapy-induced menopause Park, Jin-Hee; Jo, YuJoung; Bae, Sun HyoungPremenopausal women who receive adjuvant chemotherapy for breast cancer may undergo premature menopause. The purposes of the study were to identify the severity of menopausal symptoms and its effects on quality of life ...
Broxson, Anita ElizabethWomen diagnosed with breast cancer are often more vulnerable to the untoward effects of treatment, which may continue years beyond a diagnosis. The purpose of this study was to determine the degree to which young breast ...